This seminar will examine the historical concept of ‘plague’ from antiquity to the present using works of art, archaeological contexts, and bioarchaeology. Students will also learn the scientific principles behind each disease outbreak, including how the pathogen was first discovered; how it is currently understood by modern infectious disease experts; and how it functions within the human body and as part of ecosystems. The course will explore in particular the three pandemics of Y. pestis, malaria, and smallpox; the social impact of plagues during the ancient, medieval, early modern, and modern periods; and the history of medicine.