In this course, we will examine archaeological evidence for and art historical depictions of plagues and pandemics, beginning in antiquity and ending with the COVID-19 Pandemic. The course will explore bioarchaeological investigations of the Black Death, the Justinianic Plague, and other examples of infectious diseases with extremely high mortalities, and students will complete six “Pandemic Simulation” exercises throughout the semester. We will also consider the differing impact of plagues during the medieval, early modern, and modern periods: themes in art; the development of hospitals; and the changing ideas of disease and medicine.