The seminar begins by exploring classic scholarship centered on four historical periods, each posited as important moments in the origin of gendered science: medieval Christianity, the scientific revolution, the professionalization of scientists in the late-19th century, and 20th-century second-wave feminism. We then turn to a series of well-developed analytical tools employed by historians of science and gender, and finally to recent scholarship. In all cases, we will analyze the imbricated processes by which science as a social enterprise has been fundamentally gendered and the implicit gendering of the sciences of sex and sexuality.